Abnormalities in Copper Status Associated with an Elevated Risk of Parkinson’s Phenotype Development

In the last 15 years, among many reasons given for development of idiopathic forms Parkinson’s disease (PD), copper imbalance has been identified as a factor, and PD is often referred to copper-mediated disorder. More than 640 papers have devoted relationship between status in blood, which include following markers: total concentration, enzymatic ceruloplasmin (Cp) Cp protein level, non-ceruloplasmin level. Most studies measure only one these markers. Therefore, existence correlation still debated. Based on data from published literature, meta-analysis, our own research, it clear that there connection symptoms number atoms, are weakly associated with molecule. this work, link risk developing various inborn errors related metabolism, leading decreased levels oxidase circulation cerebrospinal fluid, discussed.